Submitted to the Department of Mechanical Engineering in Partial Fulfillment of the Requirements for the Degree of Bachelor of Science in Engineering
نویسندگان
چکیده
In order to improve nerve healing, a new treatment that uses conductive polymer scaffolds to bridge gaps between damaged nerve ends and deliver drugs controllably was explored. In order to optimize neuron growth across scaffolding a neuronal scaffold designed with an electrically conductive polymer, polypyrrole (PPy), will be used as a substrate to enhance nerve cell interaction in vitro. The polymer will be analyzed for the capacity to influence cellular phenotype, including via controlled biomolecular delivery and surface topography. This thesis showed that all these concepts are possible and begins to optimize these characteristics. Successfully optimization of these scaffold characteristics will provide a novel method for treating injury in the central nervous system. Thesis Supervisor: Robert Langer Title: Institute Professor and Professor of ChemE & BE Thesis Supervisor: Rajiv Saigal Title: Health Science and Technology Doctoral Candidate
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